Thermo-responsive polymers: Applications of smart materials in drug delivery and tissue engineering

M Sponchioni, UC Palmiero, D Moscatelli - Materials Science and …, 2019 - Elsevier
Synthetic polymers are attracting great attention in the last decades for their use in the
biomedical field as nanovectors for controlled drug delivery, hydrogels and scaffolds …

[HTML][HTML] Poly (N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications

K Nagase, M Yamato, H Kanazawa, T Okano - Biomaterials, 2018 - Elsevier
Thermoresponsive surfaces, prepared by grafting of poly (N-isopropylacrylamide)(PIPAAm)
or its copolymers, have been investigated for biomedical applications. Thermoresponsive …

Ultrasoft electronics to monitor dynamically pulsing cardiomyocytes

S Lee, D Sasaki, D Kim, M Mori, T Yokota, H Lee… - Nature …, 2019 - nature.com
In biointegrated electronics, the facile control of mechanical properties such as softness and
stretchability in electronic devices is necessary to minimize the perturbation of motions …

Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances

RZ Zhuang, R Lock, B Liu… - Nature Biomedical …, 2022 - nature.com
Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

[HTML][HTML] Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer

K Arai, D Murata, AR Verissimo, Y Mukae, M Itoh… - PloS one, 2018 - journals.plos.org
A major challenge in cardiac tissue engineering is the host's immune response to artificial
materials. To overcome this problem, we established a scaffold-free system for assembling …

Thermally-triggered fabrication of cell sheets for tissue engineering and regenerative medicine

H Takahashi, T Okano - Advanced drug delivery reviews, 2019 - Elsevier
Cell transplantation is a promising approach for promoting tissue regeneration in the
treatment of damaged tissues or organs. Although cells have conventionally been delivered …

[HTML][HTML] Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue

D Sasaki, K Matsuura, H Seta, Y Haraguchi, T Okano… - PloS one, 2018 - journals.plos.org
We have developed our original tissue engineering technology “cell sheet engineering”
utilizing temperature-responsive culture dishes. The cells are confluently grown on a …

[HTML][HTML] Antibody drug separation using thermoresponsive anionic polymer brush modified beads with optimised electrostatic and hydrophobic interactions

K Nagase, S Ishii, K Ikeda, S Yamada, D Ichikawa… - Scientific reports, 2020 - nature.com
Antibody drugs play an important role in biopharmaceuticals, because of the specificity for
target biomolecules and reduction of side effects. Thus, separation and analysis techniques …

[HTML][HTML] Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets

S Tsuruyama, K Matsuura, K Sakaguchi, T Shimizu - Regenerative therapy, 2019 - Elsevier
The purpose of this study was to fabricate pulsatile tubular cardiac tissue using cell sheet
based-tissue engineering. First, we fabricated human induced pluripotent stem cell (hiPSc) …

A novel method to align cells in a cardiac tissue‐like construct fabricated by cell sheet‐based tissue engineering

J Homma, S Shimizu, H Sekine… - Journal of Tissue …, 2020 - Wiley Online Library
Fabrication of cardiac tissue from human induced pluripotent stem cell‐derived
cardiomyocytes (hiPS‐CMs) has received great interest, but a major challenge facing …