Cancer immunotherapy (CI) is rapidly advancing and can now be considered to be the “fifth
pillar” of cancer therapy, joining the ranks of surgery, cytotoxic chemotherapy, radiation, and …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Artificial nucleic acid circuits with precisely controllable dynamic and function have shown
great promise in biosensing, but their utility in molecular diagnostics is still restrained by the …

Viral quasispecies refers to a population structure that consists of extremely large numbers
of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high …

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but
provide limited insight into the genomic diversity within tumours. Here we developed a …

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and
clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are …

Deep sequencing technologies are revealing the complexities of cancer evolution, casting
light on mutational processes fueling tumor adaptation, immune escape, and treatment …

Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity
in cancer and understanding the role of rare cells in tumor progression. These methods …

Endogenous and exogenous sources cause free radical-induced DNA damage in living
organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the …

Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to
the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA …