Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Enhanced permeability and retention effect as a ubiquitous and epoch-making phenomenon for the selective drug targeting of solid tumors

W Islam, T Niidome, T Sawa - Journal of Personalized Medicine, 2022 - mdpi.com
In 1979, development of the first polymer drug SMANCS [styrene-co-maleic acid (SMA)
copolymer conjugated to neocarzinostatin (NCS)] by Maeda and colleagues was a …

The United Kingdom's National Early Warning Score: should everyone use it? A narrative review

M Holland, J Kellett - Internal and Emergency Medicine, 2023 - Springer
This review critiques the benefits and drawbacks of the United Kingdom's National Early
Warning Score (NEWS). Potential developments for the future are considered, as well as the …

Failure mode and effect analysis (FMEA) to identify and mitigate failures in a hospital rapid response system (RRS)

E Ullah, MM Baig, H GholamHosseini, J Lu - Heliyon, 2022 - cell.com
We performed FMEA on the existing RRS with the help of routine users of the RRS who
acted as subject matter experts and evaluated the failures for their criticality using the Risk …

[HTML][HTML] Microglia and stem cells for ischemic stroke treatment—mechanisms, current status, and therapeutic challenges

A Markowska, D Koziorowski, S Szlufik - Frontiers in Bioscience …, 2023 - imrpress.com
Ischemic stroke is one of the major causes of death and disability. Since the currently used
treatment option of reperfusion therapy has several limitations, ongoing research is focusing …

Recent Advances in Blood Cell‐Inspired and Clot‐Targeted Thrombolytic Therapies

A Sheridan, AC Brown - Journal of tissue engineering and …, 2023 - Wiley Online Library
Myocardial infarction, stroke, and pulmonary embolism are all deadly conditions associated
with excessive thrombus formation. Standard treatment for these conditions involves …

Unveiling the Potent Fibrino(geno)lytic, Anticoagulant, and Antithrombotic Effects of Papain, a Cysteine Protease from Carica papaya Latex Using κ-Carrageenan Rat …

HR Yang, MN Zahan, Y Yoon, K Kim… - International Journal of …, 2023 - mdpi.com
While fibrinolytic enzymes and thrombolytic agents offer assistance in treating
cardiovascular diseases, the existing options are associated with a range of adverse effects …

Cutting-edge advances in nano/biomedicine: A review on transforming thrombolytic therapy

CH Liu, L Rethi, PW Weng, HT Nguyen… - Biochemical …, 2024 - Elsevier
Thrombotic blockages within blood vessels give rise to critical cardiovascular disorders,
including ischemic stroke, venous thromboembolism, and myocardial infarction. The current …

In-vitro and in-silico analyses of the thrombolytic potential of green kiwifruit

R Pinontoan, JS Purnomo, EB Avissa, JP Tanojo… - Scientific Reports, 2024 - nature.com
Cardiovascular diseases (CVDs), mainly caused by thrombosis complications, are the
leading cause of mortality worldwide, making the development of alternative treatments …

Secondary polycythemia and venous thromboembolism: a systematic review

A Panjwani, VS Burle, R Raj, S Thomas… - …, 2023 - f1000research.com
Background Secondary polycythemia is an acquired condition characterized by an elevation
in red blood cell (RBC) mass either in response to tissue hypoxia or inappropriate …