Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …

The honeybee (Apis mellifera) has long served as an invertebrate model organism for
reward learning and memory research. Its capacity for learning and memory formation is …

Ubiquitin-proteasome mediated protein degradation has been widely implicated in fear
memory formation in the amygdala. However, to date, the protein targets of the proteasome …

Non-ATPase regulatory subunits (Rpns) are components of the 26S proteasome involved in
polyubiquitinated substrate recognition and deubiquitination in eukaryotes. Here, we …

The honey bee is of paramount importance to humans in both agricultural and ecological
settings. Honey bee colonies have suffered from increased attrition in recent years …

Strong evidence supports that protein ubiquitination is a critical regulator of fear memory
formation. However, as this work has focused on protein degradation, it is currently unknown …

The ubiquitin-proteasome system (UPS) controls the degradation of~ 90% of short-lived
proteins in cells and is involved in activity-and learning-dependent synaptic plasticity in the …

Reduced retrograde memory performance at the cognitive level and aggregation/deposition
of amyloid beta (Aβ) in the brain at the cellular level are some of the hallmarks of Alzheimer's …

Background: Proteotoxic stress and transforming growth factor (TGFβ)-induced epithelial-
mesenchymal transition (EMT) are two main contributors of intraocular fibrotic disorders …

We investigated the in vivo role of protein degradation during intermediate (ITM) and long-
term memory (LTM) in Aplysia using an operant learning paradigm. The proteasome …