ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …

The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

DNA wraps around the histone octamer to form nucleosomes, the repeating unit of
chromatin, which create barriers for accessing genetic information. Snf2-like chromatin …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) activity is regulated by its co-factor
histone poly (ADP-ribosylation) factor 1 (HPF1). The complex formed by HPF1 and PARP1 …

Despite the importance of citrullination in physiology and disease, global identification of
citrullinated proteins, and the precise targeted sites, has remained challenging. Here we …

Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification
catalyzed by the PARP1/2: HPF1 complex. As the list of PARP1/2: HPF1 substrates …

ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …

Efficient repair of oxidized DNA is critical for genome-integrity maintenance. Cockayne
syndrome protein B (CSB) is an ATP-dependent chromatin remodeler that collaborates with …