Preterm birth remains the leading cause of morbidity and mortality among nonanomalous
neonates, and is a major public health problem. Non-Hispanic black women have a 2-fold …

Hemispheric asymmetries represent one of the major organizational principles in vertebrate
neurobiology, but their molecular determinants are not well understood. For handedness …

Background Gestational age is often used as a proxy for developmental maturity by
clinicians and researchers alike. DNA methylation has previously been shown to be …

Gestational age (GA) and birth weight have been implicated in the determination of long-
term health. It has been hypothesized that changes in DNA methylation may mediate these …

Background A sonographic short cervix (length< 25 mm during midgestation) is the most
powerful predictor of preterm birth. Current clinical practice assumes that the same cervical …

Abstract Pregnancy and childbirth represent a critical time period when a woman can be
reached through a variety of mechanisms with interventions aimed at reducing her risk of a …

Recent research efforts have provided compelling evidence of genome-wide DNA
methylation alterations in pediatrics. It is currently well established that epigenetic clocks …

Epigenetics refers to chemical modifications leading to changes in gene expression without
any alteration of the DNA structure. We suggest ways through which epigenetic mechanisms …

Background Preterm birth and shorter duration of pregnancy are associated with increased
morbidity in neonatal and later life. As the epigenome is known to have an important role …

Insulin-like growth factor 2 (IGF2) is abundantly expressed in the central nervous system
(CNS). Recent evidence highlights the role of IGF2 in the brain, sustained by data showing …