Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …

Being a rare disease, it is challenging to perform large-scale randomized control trials
(RCTs) in VCP-MSP. However, it is important to recognize potential therapeutic targets, and …

Patents play a crucial role in the drug discovery process by providing legal protection for
discoveries and incentivising investments in research and development. By identifying …

Inherited retinopathies are devastating diseases that in most cases lack treatment options.
Disease-modifying therapies that mitigate pathophysiology regardless of the underlying …

p97/VCP, a highly conserved type II ATPase associated with diverse cellular activities (AAA+
ATPase), is an important therapeutic target in the treatment of neurodegenerative diseases …

Background Pathogenic gain of function variants in Valosin-containing protein (VCP) cause
a unique disease characterized by inclusion body myopathy with early-onset Paget disease …

Pancreatic ductal adenocarcinoma (PDAC) has an extremely devastating nature with poor
prognosis and increasing incidence, making it a formidable challenge in the global fight …

Despite the recent emergence of multiple cellular and molecular strategies to restore vision
in retinal disorders, it remains unclear to what extent central visual circuits can recover when …

Simple Summary Triple negative breast cancer (TNBC) represents a clinical challenge
because its early relapse, poor overall survival and lack of effective treatments. Altered …