The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

Neurons are highly polarized cells with an elongated axon that extends far away from the
cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of …

Cross-linking mass spectrometry (XL-MS) has received considerable interest, owing to its
potential to investigate protein–protein interactions (PPIs) in an unbiased fashion in complex …

KIF1A is a kinesin family motor involved in the axonal transport of synaptic vesicle
precursors (SVPs) along microtubules (MTs). In humans, more than 10 point mutations in …

The development and proper function of the brain requires the formation of highly complex
neuronal circuitry. These circuits are shaped from synaptic connections between neurons …

Intracellular transport in neurons is driven by molecular motors that carry many different
cargos along cytoskeletal tracks in axons and dendrites. Identifying how motors interact with …

Neuronal function depends on axonal transport by kinesin superfamily proteins (KIFs).
KIF1A is the molecular motor that transports synaptic vesicle precursors, synaptic vesicles …

Postsynaptic density (PSD) proteins have been implicated in the pathophysiology of
neurodevelopmental and psychiatric disorders. Here, we present detailed clinical and …

KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in
axons. Cargo binding stimulates the dimerization of KIF1A molecules to induce processive …

Proper intracellular trafficking is essential for neuronal development and function, and when
any aspect of this process is dysregulated, the resulting “transportopathy” causes …