Simple Summary Matrix stiffness is recognized as a critical factor in cancer progression.
Recent studies have shown that matrix stiffening is caused by the accumulation, contraction …

Hepatic stellate cells (HSCs) are a significant component of the hepatocellular carcinoma
(HCC) tumor microenvironment (TME). Activated HSCs transform into myofibroblast-like …

Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …

A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …

Abstract Purpose of the Review This review aims to summarize the current knowledge of the
extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions …

Liver fibrosis is the common consequence of various chronic liver injuries and is mainly
characterized by the imbalance between the production and degradation of extracellular …

Liver fibrosis, a condition characterized by extensive deposition and cross-linking of
extracellular matrix (ECM) proteins, is idiosyncratic in cases of chronic liver injury. The …

Over the last two decades, our understanding of the pathological role of hepatic stellate cells
(HSCs) in fibrotic liver disease has increased dramatically. As HSCs are identified as the …

Simple Summary The progression of liver tumors is highly influenced by the interactions
between cancer cells and the surrounding environment, and, consequently, can determine …