Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It
affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion …

The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of
the many factors that is accountable for the development of hypertension. The five dopamine …

Background: This work evaluates the effect of a low‐sodium diet on clinical and
neurohumoral parameters and on renal dopaminergic system activity in heart failure (HF) …

We have previously reported that age-associated oxidative stress via protein kinase C (PKC)
increases D1 receptor (D1R) phosphorylation and causes D1R-G protein uncoupling in …

The C57Bl/6J mouse strain, the genetic background of many transgenic and gene knockout
models, is salt sensitive and resistant to renal injury. We tested the hypothesis that renal …

Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR
immortalized renal proximal tubular cells. Background Spontaneously hypertensive rats …

Kidneys play a vital role in long-term regulation of blood pressure. This is achieved by
actions of many renal and nonrenal factors acting on the kidney that help maintain the …

Dopamine is important in the pathogenesis of hypertension because of abnormalities in
receptor-mediated regulation of renal sodium transport. Dopamine receptors are classified …

Salt (sodium chloride) is an essential dietary requirement, but excessive consumption has
long-term adverse consequences. A high-salt diet (HSD) increases the risk of chronic …

The present study examined the functional characteristics of the inward and outward l-[14C]
DOPA and l-[14C] leucine transporters in LLC-PK1 cells. Uptake was initiated by the …