Microglia are the most abundant immune cells in the central nervous system (CNS), where
they interact with neurons and exhibit a wide array of functions in physiological and …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

Over the last decade the important concept has emerged that microglia, similar to other
tissue macrophages, assume different phenotypes and serve several effector functions …

The study of the dynamics and functions of microglia in the healthy and diseased brain is a
matter of intense scientific activity. The application of new techniques and new experimental …

Neuroinflammatory changes play a pivotal role in the progression of Parkinson's disease
(PD) pathogenesis. Recent findings have suggested that activated microglia may polarize …

Neuroinflammation is a hostdefense mechanism associated with restoration of normal
structure and function of the brain and neutralization of an insult. Increasing …

Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of
central nervous system (CNS) functionality. It has been shown that neuroinflammation …

Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused
by a complex interplay of genetic and environmental factors. Information on various aspects …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

Abstract The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used to induce models of
Parkinson's disease (PD). We now know that the model induced by 6-OHDA does not …