Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

The concept of 'idiopathic'Parkinson's disease (PD) as a single entity has been challenged
with the identification of several clinical subtypes, pathogenic genes and putative causative …

Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …

While ultrasound is most widely known for its use in diagnostic imaging, the energy carried
by ultrasound waves can be utilized to influence cell function and drug delivery …

Background The subthalamic nucleus is the preferred neurosurgical target for deep-brain
stimulation to treat cardinal motor features of Parkinson's disease. Focused ultrasound is an …

Ultrasound‐based brain stimulation techniques may become a powerful new technique to
modulate the human brain in a focal and targeted manner. However, for clinical brain …

When James Parkinson described the classical symptoms of the disease he could hardly
foresee the evolution of our understanding over the next two hundred years. Nowadays …

Advanced Parkinson's disease is characterized by the presence of motor fluctuations,
various degree of dyskinesia, and disability with functional impact on activities of daily living …