In mammals, the p53 family comprises two additional members, p63 and p73 (hereafter
referred to as TP 53, TP 63, and TP 73, respectively). The usage of two alternative promoters …

TRIM-NHL proteins are key regulators of developmental transitions, for example promoting
differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells …

Metastasizing cancer cells are able to withstand high levels of oxidative stress through
mechanisms that are poorly understood. Here, we show that under various oxidative stress …

Polymerase basic protein 1 (PB1) is the catalytic core of the influenza A virus (IAV) RNA
polymerase complex essential for viral transcription and replication. Understanding the …

Tumor suppressor p53 has a key role in maintaining genomic stability and preventing
tumorigenesis through its regulation of cellular stress responses, including apoptosis, cell …

The ubiquitin proteasome system (UPS) plays a role in the regulation of most cellular
pathways, and its deregulation has been implicated in a wide range of human pathologies …

The balance between stem cell maintenance and differentiation has been proposed to
depend on antagonizing ubiquitination and deubiquitination reactions of key stem cell …

The tumor suppressor p53 and its homologues, p63 and p73, play a pivotal role in the
regulation of the DNA damage response, cellular homeostasis, development, aging, and …

Functional inactivation of wild-type p53 is a major trait of cancerous cells. In many cases,
such inactivation occurs by either TP53 gene mutations or due to overexpression of p53 …

Tripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by
the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is …