Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

Estrogen and insulin-like-growth factor 1 (IGF-1) are potent mitogenic stimuli that share
important properties in the control of cellular proliferation. However, the coupling between …

I. Introduction IT HAS been known for several years that steroid hormones function through
the action of specific receptor proteins. In target tissues, receptors are activated by hormonal …

G ENE regulation by steroid hormones is mediated by binding of the hormone ligand to the
corresponding receptor that triggers a complex set of interactions of the hormone receptors …

Using a transient co‐transfection system, we show that the human oestrogen receptor (hER)
becomes phosphorylated in the presence of oestradiol (E2) as well as in the presence of the …

Antiestrogen therapy remains one of the most widely used and effective treatments for the
management of endocrine responsive breast cancers. This reflects the ability of …

SUMMARY A remarkable diversity of naturally occurring and synthetic compounds have
been shown to mimic the biological effects of 17fl-estradiol by virtue of their ability to bind to …

Aberrant activation of the androgen receptor through signaling pathways independent of
androgen may be responsible for the progression of prostate tumors to the rapidly …

In addition to the conventional hormone-dependent regulation of the activity of
steroid/thyroid receptor family members, many studies have shown that there is substantial …