The status of tuberculosis vaccine development

LK Schrager, J Vekemens, N Drager… - The Lancet Infectious …, 2020 - thelancet.com
Tuberculosis represents the leading global cause of death from an infectious agent.
Controlling the tuberculosis epidemic thus represents an urgent global public health priority …

Progress in tuberculosis vaccine development and host-directed therapies—a state of the art review

SHE Kaufmann, C Lange, M Rao, KN Balaji… - The lancet Respiratory …, 2014 - thelancet.com
Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …

Novel vaccination strategies against tuberculosis

P Andersen, SHE Kaufmann - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
The tuberculosis (TB) pandemic continues to rampage despite widespread use of the BCG
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …

The current status, challenges, and future developments of new tuberculosis vaccines

W Gong, Y Liang, X Wu - Human vaccines & immunotherapeutics, 2018 - Taylor & Francis
Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of
death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain …

[HTML][HTML] Vaccination against tuberculosis: revamping BCG by molecular genetics guided by immunology

SHE Kaufmann - Frontiers in immunology, 2020 - frontiersin.org
Tuberculosis (TB) remains a major health threat. Although a vaccine has been available for
almost 100 years termed Bacille Calmette-Guérin (BCG), it is insufficient and better vaccines …

Tuberculosis vaccines: time to think about the next generation

SHE Kaufmann - Seminars in immunology, 2013 - Elsevier
Efforts over the last 2 decades have led to a rich research and development pipeline of
tuberculosis (TB) vaccines. Although none of the candidates has successfully completed the …

[HTML][HTML] Clinical development of new TB vaccines: recent advances and next steps

M Hatherill, RG White, TR Hawn - Frontiers in microbiology, 2020 - frontiersin.org
Mycobacterium tuberculosis (Mtb) kills more people worldwide than any single infectious
pathogen, yet the only vaccine licensed against tuberculosis, Bacille Calmette Guerin (BCG) …

Novel strategies to combat the emerging drug resistance in human pathogenic microbes

H Qadri, AH Shah, M Mir - Current Drug Targets, 2021 - ingentaconnect.com
The major health-care burden for the developing world are infectious diseases where
antimicrobial agents prove to be the magical drugs to combat this. But the phenomenon of …

Novel drugs against tuberculosis: a clinician's perspective

ID Olaru, F von Groote-Bidlingmaier… - European …, 2015 - Eur Respiratory Soc
The United Nations Millennium Development Goal of reversing the global spread of
tuberculosis by 2015 has been offset by the rampant re-emergence of drug-resistant …

[HTML][HTML] Research and development of new tuberculosis vaccines: a review

LK Schrager, RC Harris, J Vekemans - F1000Research, 2018 - ncbi.nlm.nih.gov
Tuberculosis kills more people worldwide than any other single infectious disease agent, a
threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis …