[HTML][HTML] Molecular correlates of vaccine-induced protection against typhoid fever

H Zhu, I Chelysheva, DL Cross… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella
enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines …

[HTML][HTML] Controlled human infectious models, a path forward in uncovering immunological correlates of protection: Lessons from enteric fevers studies

MB Sztein, JS Booth - Frontiers in microbiology, 2022 - frontiersin.org
Enteric infectious diseases account for more than a billion disease episodes yearly
worldwide resulting in approximately 2 million deaths, with children under 5 years old and …

[HTML][HTML] Scalable production and immunogenicity of a cholera conjugate vaccine

S Jeon, M Kelly, J Yun, B Lee, M Park, Y Whang, C Lee… - Vaccine, 2021 - Elsevier
There is a need to develop cholera vaccines that are protective in young children under 5
years of age, which induce long-term immunity, and which can be incorporated into the …

[HTML][HTML] The route of vaccine administration determines whether blood neutrophils undergo long-term phenotypic modifications

Y Feraoun, JL Palgen, C Joly, N Tchitchek… - Frontiers in …, 2022 - frontiersin.org
Innate immunity modulates adaptive immunity and defines the magnitude, quality, and
longevity of antigen-specific T-and B-cell immune memory. Various vaccine and …

[HTML][HTML] Association of antibody-dependent neutrophil phagocytosis with distinct antibody glycosylation profiles following typhoid vaccination

M Johnson, L Stockdale, N de Haan… - Frontiers in Tropical …, 2021 - frontiersin.org
Typhoid Vi-conjugate vaccines (Vi-TCV) have been developed to control typhoid fever in
children in endemic regions. Previously, in a human challenge model of typhoid, Vi-TCV …

[HTML][HTML] Intranasal immunization of mice with chimera of Salmonella Typhi protein elicits protective intestinal immunity

S Chakraborty, P Dutta, A Pal, S Chakraborty, G Banik… - npj Vaccines, 2024 - nature.com
Abstract Development of safe, highly effective and affordable enteric fever vaccines is a
global health priority. Live, oral typhoid vaccines induce strong mucosal immunity and long …

Intranasal Immunization of Mice with a Chimeric Antigen of Cholera Toxin B and Salmonella Typhi outer membrane protein T2544 elicits protective antibodies and T …

S Chakraborty, P Dutta, A Pal, S Chakraborty, G Banik… - 2023 - researchsquare.com
Abstract Development of safe, highly effective and affordable enteric fever vaccines is a
global health priority. Live, oral typhoid vaccines induce strong mucosal immunity and long …

[HTML][HTML] Persistence of antibody after a Vi-tetanus toxoid conjugate vaccine and effect of boosting with a plain polysaccharide vaccine on Vi antibody and antigen …

T Bentley, E Jones, C Jin, M Moore… - Frontiers in Tropical …, 2021 - frontiersin.org
Background Salmonella enterica serovar Typhi is estimated to cause 9 to 13 million cases of
typhoid fever annually. Typhoid conjugate vaccines represent a promising prophylactic …