Focus on PTEN regulation

M Bermúdez Brito, E Goulielmaki… - Frontiers in …, 2015 - frontiersin.org
The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor
suppressor has been for a long time attributed to its lipid phosphatase activity against PI (3 …

[HTML][HTML] Focus on PTEN regulation

MB Brito, E Goulielmaki, EA Papakonstanti - Frontiers in oncology, 2015 - ncbi.nlm.nih.gov
The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor
suppressor has been for a long time attributed to its lipid phosphatase activity against PI (3 …

Epidemiology, major risk factors and genetic predisposition for breast cancer in the Pakistani population

U Shaukat, M Ismail, N Mehmood - Asian Pacific Journal of …, 2013 - journal.waocp.org
Occurrence of breast cancer is related to genetic as well as cultural, environmental and life-
style factors. Variations in diversity of these factors among different ethnic groups and …

Redox Regulation of PTEN by Reactive Oxygen Species: Its Role in Physiological Processes

VH Trinh, T Nguyen Huu, DK Sah, JM Choi, HJ Yoon… - Antioxidants, 2024 - mdpi.com
Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate
cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In …

Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer

AS Al-Wajeeh, SM Salhimi, MA Al-Mansoub, IA Khalid… - PLoS …, 2020 - journals.plos.org
Background Breast cancer is the fifth most prevalent cause of death among women
worldwide. It is also one of the most common types of cancer among Malaysian women. This …

Roles of PTEN (Phosphatase and Tensin Homolog) in gastric cancer development and progression

WT Xu, Z Yang, NH Lu - Asian Pacific Journal of Cancer …, 2014 - koreascience.kr
Gastric cancer is highly invasive, aggressively malignant, and amongst the most prevalent of
all forms of cancer. Despite improved management strategies, early stage diagnosis of …

Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors

W Xu, Z Yang, SF Zhou, N Lu - Drug design, development and …, 2014 - Taylor & Francis
The incidence of cancer is increasing worldwide, but the biochemical mechanisms for the
occurrence of cancer is not fully understood, and there is no cure for advanced tumors …

[Retracted] Human Schlafen 5 Inhibits Proliferation and Promotes Apoptosis in Lung Adenocarcinoma via the PTEN/PI3K/AKT/mTOR Pathway

X Gu, L Zhou, L Chen, H Pan, R Zhao… - BioMed Research …, 2021 - Wiley Online Library
Background. Human Schlafen 5 (SLFN5) is reported to inhibit or promote the proliferation of
several specific types of cancer cells by our lab and other researchers. We are curious about …

Potential role of VHL, PTEN, and BAP1 mutations in renal tumors

K Szegedi, Z Szabó, J Kállai, J Király, E Szabó… - Journal of Clinical …, 2023 - mdpi.com
The genetic profiling of renal tumors has revealed genomic regions commonly affected by
structural changes and a general genetic heterogeneity. The VHL, PTEN, and BAP1 genes …

Arsenic trioxide induces G2/M arrest in hepatocellular carcinoma cells by increasing the tumor suppressor PTEN expression

X Zhang, S Jia, S Yang, Y Yang… - Journal of cellular …, 2012 - Wiley Online Library
Abstract Arsenic trioxide (As2O3), an effective agent against acute promyelocytic leukemia,
has been reported to inhibit the viability of solid tumors cell lines recently. The detailed …