RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …

Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

Aims Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling
represents an early event in the clinical course leading to heart failure. Maladaptive …

Genome-wide studies have revealed that mammalian genomes are pervasively transcribed.
This has led to the identification and isolation of novel classes of non-coding RNAs …

Abstract Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly
expressed in the myocardium. They play a central role in cardiogenesis, heart function and …

Abstract Aims Circulating microRNAs (miRNAs) may represent a novel class of biomarkers;
therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma …

Cardiovascular disease is the predominant cause of human morbidity and mortality in
developed countries. Thus, extraordinary effort has been devoted to determining the …

Background—A characteristic of both clinical and experimental atrial fibrillation (AF) is atrial
electric remodeling associated with profound reduction of L-type Ca2+ current and …

Recent studies have revealed the role of microRNAs (miRNAs) in a variety of basic
biological and pathological processes and the association of miRNA signatures with human …

Early reperfusion of ischemic cardiac tissue remains the most effective intervention for
improving clinical outcome following myocardial infarction. However, abnormal increases in …