Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression

JL Chen, B Du - Journal of cancer research and clinical oncology, 2019 - Springer
Purpose The fat mass-and obesity-associated (FTO) gene on chromosome 16q12. 2 shows
an intimate association with obesity and body mass index. Recently, research into the FTO …

The effects of DNA methylation on human psychology

F Kader, M Ghai, L Maharaj - Behavioural brain research, 2018 - Elsevier
DNA methylation is a fundamental epigenetic modification in the human genome; pivotal in
development, genomic imprinting, X inactivation, chromosome stability, gene expression …

DNA methylation-based variation between human populations

F Kader, M Ghai - Molecular genetics and genomics, 2017 - Springer
Several studies have proved that DNA methylation affects regulation of gene expression and
development. Epigenome-wide studies have reported variation in methylation patterns …

[HTML][HTML] Milk's role as an epigenetic regulator in health and disease

BC Melnik, G Schmitz - Diseases, 2017 - mdpi.com
It is the intention of this review to characterize milk's role as an epigenetic regulator in health
and disease. Based on translational research, we identify milk as a major epigenetic …

[HTML][HTML] Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases

BC Melnik - Journal of translational medicine, 2015 - Springer
Single-nucleotide polymorphisms within intron 1 of the FTO (fat mass and obesity-
associated) gene are associated with enhanced FTO expression, increased body weight …

[HTML][HTML] Lifetime impact of cow's milk on overactivation of mTORC1: From fetal to childhood overgrowth, acne, diabetes, cancers, and neurodegeneration

BC Melnik - Biomolecules, 2021 - mdpi.com
The consumption of cow's milk is a part of the basic nutritional habits of Western
industrialized countries. Recent epidemiological studies associate the intake of cow's milk …

DNA methylation across the tree of life, from micro to macro-organism

Nasrullah, A Hussain, S Ahmed, M Rasool… - …, 2022 - Taylor & Francis
ABSTRACT DNA methylation is a process in which methyl (CH3) groups are added to the
DNA molecule. The DNA segment does not change in the sequence, but DNA methylation …

DNA methylation changes and inflammaging in aging-associated diseases

M Alimohammadi, S Makaremi, A Rahimi… - …, 2022 - Future Medicine
Aging as an inevitable phenomenon is associated with pervasive changes in physiological
functions. There is a relationship between aging and the increase of several chronic …

[HTML][HTML] DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus

Z Zhou, B Sun, X Li, C Zhu - Nutrition & metabolism, 2018 - Springer
Although genetic variations and environmental factors are vital to the development and
progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics …

[HTML][HTML] DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome

SD van Otterdijk, AM Binder, K Szarc vel Szic… - PLoS …, 2017 - journals.plos.org
Introduction The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is
increasing and several studies suggested an involvement of DNA methylation in the …