Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …

Base excision repair (BER) corrects DNA damage from oxidation, deamination and
alkylation. Such base lesions cause little distortion to the DNA helix structure. BER is …

The large mitochondrial genomes of angiosperms are unusually dynamic because of
recombination activities involving repeated sequences. These activities generate …

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …

Emerging gene therapy approaches that aim to eliminate pathogenic mutations of
mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the …

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …

Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging
humans have increased levels of somatic mtDNA mutations that tend to undergo clonal …

If not properly processed and repaired, DNA double-strand breaks (DSBs) can give rise to
deleterious chromosome rearrangements, which could ultimately lead to the tumour …