The suprachoroidal space as a route of administration to the posterior segment of the eye

B Chiang, JH Jung, MR Prausnitz - Advanced drug delivery reviews, 2018 - Elsevier
The suprachoroidal space (SCS) is a potential space between the sclera and choroid that
traverses the circumference of the posterior segment of the eye. The SCS is an attractive site …

Suprachoroidal injection: a novel approach for targeted drug delivery

KY Wu, JK Fujioka, T Gholamian, M Zaharia, SD Tran - Pharmaceuticals, 2023 - mdpi.com
Treating posterior segment and retinal diseases poses challenges due to the complex
structures in the eye that act as robust barriers, limiting medication delivery and …

[HTML][HTML] Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina

W Xie, M Zhao, SH Tsai, WL Burkes, LB Potts… - Experimental eye …, 2018 - Elsevier
Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for
retinal morphological assessment in vivo. Information on the correlation of SD-OCT with …

Treating tissue factor–positive cancers with antibody–drug conjugates that do not affect blood clotting

JW Theunissen, AG Cai, MM Bhatti, AB Cooper… - Molecular Cancer …, 2018 - AACR
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood
clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on …

[HTML][HTML] Porcine models of choroidal neovascularization: A systematic review

TS Jakobsen, BK Fabian-Jessing, S Hansen… - Experimental Eye …, 2023 - Elsevier
Animal models of choroidal neovascularization (CNV) are extensively used in translational
studies of CNV formation and to evaluate angiostatic treatment strategies. However, the …

Progress in the Application of Microneedles in Eye Disorders and the Proposal of the Upgraded Microneedle with Spinule

Q Yang, T Zhang, Y Wu, Q Liang, W Zhao, R Liu… - Pharmaceutical …, 2024 - Springer
Purpose In the local administration methods for treating eye diseases, the application of
microneedles has great potential due to the shortcomings of low efficacy and significant side …

[HTML][HTML] Drug tissue distribution of TUDCA from a biodegradable suprachoroidal implant versus intravitreal or systemic delivery in the pig model

TW Olsen, RB Dyer, F Mano… - … Vision Science & …, 2020 - jov.arvojournals.org
Purpose: To determine local ocular tissue levels of the bile acid, tauroursodeoxycholic acid
(TUDCA), in the pig model using oral, intravenous (IV), intravitreal injection (IVitI) and low …

Identification of endogenous microRNA references in porcine serum for quantitative real-time PCR normalization

IS Bae, KS Seo, SH Kim - Molecular biology reports, 2018 - Springer
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate the
expression of genes, and they affect important biological and physiological states …

Advanced Technologies of Drug Delivery to the Posterior Eye Segment Targeting Angiogenesis and Ocular Cancer

M Ansari, YA Kulkarni, K Singh - Critical Reviews™ in …, 2024 - dl.begellhouse.com
Retinoblastoma (RB), a childhood retinal cancer is caused due to RB1 gene mutation which
affects the child below 5 years of age. Angiogenesis has been proven its role in RB …

[HTML][HTML] The effect on wound healing of pazopanib and bevacizumab compared with corticosteroid in experimental glaucoma filtration surgery

SG Kobat, FU Celiker, AF Dagli… - International Journal of …, 2018 - ncbi.nlm.nih.gov
AIM To compare the effects of bevacizumab and pazopanib with corticosteroids on wound
healing after trabeculectomy. METHODS In the study, 35 New Zealand white rabbits were …