Protein misfolding and aggregation have been associated with several human disorders,
including Alzheimer's, Parkinson's and Huntington's diseases, as well as senile systemic …

Stereochemistry is a very important issue for the pharmaceutical industry and can determine
drug efficacy. The design and synthesis of small molecules, especially chiral molecules …

Self-assembly of amyloid β-protein (Aβ) into neurotoxic oligomers and fibrillar aggregates is
a key process thought to be the proximal event leading to development of Alzheimer's …

Sulfonamide linker-based inhibitors with extended linear structure were designed and
synthesized with the aim of producing multifunctional agents against several processes …

The design, synthesis and assessment of β-carboline core-based compounds as potential
multifunctional agents against several processes that are believed to play a significant role …

A series of compounds containing an α, β-unsaturated carbonyl moiety, such as chalcones
and coumarins were designed, synthesized and tested in a variety of assays to assess their …

A Lewis acid promoted Csp3–H bond functionalization of methyl azaarenes with α-
trifluoromethylated carbonyl compounds is described. Catalytic amounts of Yb (OTf) 3 …

Alzheimer's disease (AD) is a serious health concern, affecting millions of people globally,
which leads to cognitive impairment, dementia, and inevitable death. There is still no …

The design and application of an effective, new class of multifunctional small molecule
inhibitors of amyloid self-assembly are described. Several compounds based on the diaryl …

An enantioselective hydroxyalkylation of indoles and 7‐azaindole with trifluoromethyl
ketones was found to be effectively promoted under high‐pressure conditions with a low …