In the last decades, the development of high‐throughput molecular assays has
revolutionised cancer diagnostics, paving the way for the concept of personalised cancer …

In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not
been consistently validated clinically. We trained a TP53-loss phenocopy gene expression …

Guidelines in statistical modeling for genomics hold that simpler models have advantages
over more complex ones. Potential advantages include cost, interpretability, and improved …

Current predictive biomarkers generally leverage technologies such as immunohis-
tochemistry or genetic analysis, which may require specialized equipment, be time-intensive …

The response envelope model proposed by Cook et al. is an efficient method to estimate the
regression coefficient under the context of the multivariate linear regression model. It …

Motivation Most models can be fit to data using various optimization approaches. While
model choice is frequently reported in machine-learning-based research, optimizers are not …

Methods of generating phenocopy signatures and uses thereof. The methods of generating
phenocopy signatures can include determining gene expression signatures that predict the …