The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

Background SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release
of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of …

SARS-CoV-2 is a positive-strand RNA virus that infects humans through the nasopharyngeal
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …

The on-going pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to unprecedented medical and …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, is a highly transmittable and pathogenic human coronavirus that first emerged in …

With global expansion of the COVID-19 pandemic and the emergence of new variants,
extensive efforts have been made to develop highly effective antiviral drugs and vaccines …

Replication of the 30-kilobase genome of SARS-CoV-2, responsible for COVID-19, is a key
step in the coronavirus life cycle that requires a set of virally encoded nonstructural proteins …

Ubiquitin signaling is essential for immunity to restrict pathogen proliferation. Due to its
enormous impact on human health and the global economy, intensive efforts have been …