Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …

Post-translational lipid modifications farnesylation and geranylgeranylation of proteins
(protein prenylation) have been identified to mediate critical events in cancer, cardiovascular …

Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent
drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to …

Malaria parasites rely on a plastid organelle for survival during the blood stages of infection.
However, the entire organelle is dispensable as long as the isoprenoid precursor …

Malaria remains a major health problem, especially because of the emergence of resistant
P. falciparum strains to artemisinin derivatives. In this context, safe and affordable …

Malaria is a global health problem that causes significant mortality and morbidity annually
and a serious problem to drug therapy and discovery as current anti-malarial therapeutics …

Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases
involved in human host hemoglobin degradation and other processes like erythrocyte …

Infectious diseases caused by bacteria, viruses, parasites and fungi, and their interaction
with hosts and the environment are a global public health threat. In antimicrobial drug …

Background The spread of artemisinin (ART)-resistant Plasmodium falciparum threatens the
control of malaria. Mutations in the propeller domains of P. falciparum Kelch13 (k13) are …

Background and research purpose Paeoniflorin and albiflorin are monoterpene glycosides
that exhibit various medicinal properties in Paeonia species. This study explored the terpene …