Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …

Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …

Over the centuries, cancer has been considered one of the significant health threats. It holds
the position in the list of deadliest diseases over the globe. In women, breast cancer is the …

The CDK8–cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C
remains undruggable. Modulators regulating cyclin C activity directly are still under …

Triple-negative breast cancers (TNBC) are treated primarily by chemotherapy and lack
clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR …

Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of
breast cancer with limited options for therapy. Cancer development and maintenance is …

ABSTRACT Introduction Hydrophobic tagging (HyT) technology presents a distinct
therapeutic strategy diverging from conventional small molecule drugs, providing an …

Background Genetic alterations are well characterized as contributors to the pathogenesis of
cancers. Epigenetic abnormalities can lead to perturbations of the expression of genes in …

Protein lactylation represents a pervasive post-translational modification prevalent in
histones and diverse proteins, fostering tumor initiation and progression. Nonetheless, the …