Many biological processes are executed and regulated through the molecular interactions of
proteins and nucleic acids. Proximity labeling (PL) is a technology for tagging the …

The interaction of proteins and RNA with chromatin underlies the regulation of gene
expression. The ability to profile easily these interactions is fundamental for understanding …

Conclusions FXR sulfhydration is a post‐translational modification affected by hepatic
endogenous CSE/H 2 S that may promote FXR activity and attenuate NAFLD. Hepatic CSE …

Tn5 transposase use in biotechnology has substantially advanced the sequencing
applications of genome-wide analysis of cells. This is mainly due to the ability of Tn5 …

Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With
sequencing costs continuously dropping and our ability to generate large datasets rising …

Apurinic/apyrimidinic (AP) sites are the most common DNA lesions, which benefit from a
most efficient repair by the base excision pathway. The impact of losing a nucleobase on the …

Protein− nucleic acid interactions, including the interac-tions of proteins with DNA, RNA, and
DNA/RNA hybrid, often confer important biological consequences to targeted nucleic acids …

Epigenetic regulation plays a pivotal role in various biological and disease processes. Two
key lines of investigation have been pursued that aim to unravel endogenous epigenetic …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) has revolutionized the
studies of epigenomes and the massive increase in ChIP-seq datasets calls for robust and …

The biogenesis of RNAs is a multi-layered and highly regulated process that involves a
diverse set of players acting in an orchestrated manner throughout the transcription cycle …