Medicinal importance and chemosensing applications of pyridine derivatives: a review

G Mohammad Abu-Taweel, MM Ibrahim… - Critical Reviews in …, 2024 - Taylor & Francis
Pyridine derivatives are the most common and significant heterocyclic compounds, which
play an important role in various fields ranging from medicinal to chemosensing …

A therapeutic journey of pyridine-based heterocyclic compounds as potent anticancer agents: a review (from 2017 to 2021)

M Alrooqi, S Khan, FA Alhumaydhi… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Pyridine derivatives are the most common and significant heterocyclic compounds, which
show their fundamental characteristics to various pharmaceutical agents and natural …

[HTML][HTML] Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases

X Jin, GY Yang - Progress in Lipid Research, 2023 - Elsevier
Glycosphingolipids (GSLs) are major amphiphilic glycolipids present on the surface of living
cell membranes. They have important biological functions, including maintaining plasma …

Deciphering the importance of glycosphingolipids on cellular and molecular mechanisms associated with epithelial-to-mesenchymal transition in cancer

C Cumin, YL Huang, A Everest-Dass, F Jacob - Biomolecules, 2021 - mdpi.com
Every living cell is covered with a dense and complex layer of glycans on the cell surface,
which have important functions in the interaction between cells and their environment …

Structure and function of glycosphingolipids on small extracellular vesicles

X He, F Guan, L Lei - Glycoconjugate Journal, 2022 - Springer
Extracellular vesicles (EVs) are membrane-delineated particles secreted by most types of
cells under both normal and pathophysiological conditions. EVs are believed to mediate …

A combination of a cell penetrating peptide and a protein translation inhibitor kills metastatic breast cancer cells

L Rowland, HB Marjault, O Karmi, DA Grant… - Cell Death …, 2023 - nature.com
Abstract Cell Penetrating Peptides (CPPs) are promising anticancer and antimicrobial drugs.
We recently reported that a peptide derived from the human mitochondrial/ER membrane …

Novel Thieno [2,3-b]pyridine Anticancer Compound Lowers Cancer Stem Cell Fraction Inducing Shift of Lipid to Glucose Metabolism

M Pervan, S Marijan, A Markotić, LI Pilkington… - International journal of …, 2022 - mdpi.com
Due to the role of cancer stem cells (CSCs) in tumor resistance and glycosphingolipid (GSL)
involvement in tumor pathogenesis, we investigated the effect of a newly synthesized …

Bioactive sphingolipids as emerging targets for signal transduction in cancer development

W Jia, J Yuan, J Zhang, S Li, W Lin, B Cheng - Biochimica et Biophysica …, 2024 - Elsevier
Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells

S Marijan, A Mastelić, A Markotić, N Režić-Mužinić… - Medicines, 2021 - mdpi.com
The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous
metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It …

Functions of Sialyltransferases in Gynecological Malignancies: a systematic review

S Sun, Z Yang, M Majdaeen, AT Agbele… - … -Research and Practice, 2024 - Elsevier
Introduction The biosynthesis of tumor-associated sialoglycans involves Sialyltransferases
expressed in cancer cells differentially. The current review aspires to bridge the existing …