Cancer gene therapy: fringe or cutting edge?
F McCormick - Nature Reviews Cancer, 2001 - nature.com
Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …
basis of its molecular characteristics. But although laboratory results have been extremely …
[HTML][HTML] Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management
HT Lynch, MJ Casey, CL Snyder, C Bewtra, JF Lynch… - Molecular …, 2009 - Elsevier
Hereditary ovarian cancer accounts for at least 5% of the estimated 22,000 new cases of this
disease during 2009. During this same time, over 15,000 will die from malignancy ascribed …
disease during 2009. During this same time, over 15,000 will die from malignancy ascribed …
Endometrial carcinoma
A Di Cristofano, LH Ellenson - Annu. Rev. Pathol. Mech. Dis., 2007 - annualreviews.org
Endometrial carcinoma, a common malignancy of the female genital tract, is composed of a
number of tumor types with different light-microscopic features, molecular genetic …
number of tumor types with different light-microscopic features, molecular genetic …
Phase II trial of combination bevacizumab and temsirolimus in the treatment of recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study
EA Alvarez, WE Brady, JL Walker, J Rotmensch… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: This two-stage phase II study was designed to assess the activity of the
combination of temsirolimus and bevacizumab in patients with recurrent or persistent …
combination of temsirolimus and bevacizumab in patients with recurrent or persistent …
PTEN and TNF-α regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-κB–dependent pathway
S Kim, C Domon-Dell, Q Wang, DH Chung… - Gastroenterology, 2002 - Elsevier
Background & Aims: PTEN (phosphatase and tensin homologue deleted from chromosome
10) is a dual-specificity phosphatase implicated in embryonic development, intestinal cell …
10) is a dual-specificity phosphatase implicated in embryonic development, intestinal cell …
AKT involvement in cisplatin chemoresistance of human uterine cancer cells
V Gagnon, I Mathieu, É Sexton, K Leblanc… - Gynecologic …, 2004 - Elsevier
Objective. The aim of this study was to investigate the possible involvement of Akt activity
and specific isoforms (Akt1, Akt2, and Akt3) in the resistance of human uterine cancer cells …
and specific isoforms (Akt1, Akt2, and Akt3) in the resistance of human uterine cancer cells …
[HTML][HTML] Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-α/nuclear factor-κB (NF-κB)-inducing kinase/NF-κB pathway is linked to a default …
S Kim, C Domon-Dell, J Kang, DH Chung… - Journal of Biological …, 2004 - ASBMB
The PTEN (phosphatase and tensin homolog deleted on chromosome ten) tumor
suppressor gene affects multiple cellular processes including cell growth, proliferation, and …
suppressor gene affects multiple cellular processes including cell growth, proliferation, and …
Inhibition of the phosphatidylinositol 3-kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation
Q Wang, X Wang, A Hernandez, S Kim, BM Evers - Gastroenterology, 2001 - Elsevier
Background & Aims: Phosphatidylinositol 3-kinase (PI3K), an important mediator of
intracellular signal transduction, has been shown to affect proliferation, differentiation, and …
intracellular signal transduction, has been shown to affect proliferation, differentiation, and …
[HTML][HTML] Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells
Q Wang, X Wang, A Hernandez, MR Hellmich… - Journal of Biological …, 2002 - ASBMB
The intestinal mucosa is a rapidly-renewing tissue characterized by cell proliferation,
differentiation, and eventual apoptosis with progression up the vertical gut axis. The …
differentiation, and eventual apoptosis with progression up the vertical gut axis. The …
In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin
M Tanaka, HB Grossman - Gene therapy, 2003 - nature.com
The PTEN gene, located on chromosome 10, is a phosphatase in the phosphatidylinositol
3′-kinase (PI3'K)-mediated signal transduction pathway. PTEN inhibits the activation of Akt …
3′-kinase (PI3'K)-mediated signal transduction pathway. PTEN inhibits the activation of Akt …