Cerebral postischemic reperfusion injury is defined as deterioration of ischemic brain tissue
that parallels and antagonizes the benefits of restoring cerebral circulation after therapeutic …

Ischaemic stroke is one of the leading causes of death and disability worldwide, and
intravenous alteplase is the only proven effective treatment in the acute setting. Hypothermia …

Background and Purpose—Induced hypothermia is a promising neuroprotective therapy.
We studied the feasibility and safety of hypothermia and thrombolysis after acute ischemic …

Background and Purpose—Therapeutic hypothermia is a potent neuroprotectant approved
for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic …

Stroke is one of the leading causes of death and disability worldwide. Current treatment
strategies for ischemic stroke primarily focus on reducing the size of ischemic damage and …

Therapeutic hypothermia is a means of neuroprotection well established in the management
of acute ischemic brain injuries such as anoxic encephalopathy after cardiac arrest and …

Therapeutic hypothermia, recently termed target temperature management (TTM), is the
cornerstone of neuroprotective strategy. Dating to the pioneer works of Fay, nearly 75 years …

Background and Purpose—The search for effective neuroprotectants remains frustrating,
particularly with regard to specific pharmaceuticals. However, laboratory studies have …

Malignant cerebral edema following ischemic stroke is life threatening, as it can cause
inadequate blood flow and perfusion leading to irreversible tissue hypoxia and metabolic …

So far, intravenous tissue-type plasminogen activator (tPA) and mechanical removal of
arterial blood clot (thrombectomy) are the only available treatments for acute ischemic …