Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

Carrageenan (CRG) is a family of natural polysaccharides derived from seaweeds and has
widely been used as food additives. In the past decade, owing to its attractive …

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by
nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …

Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate
causes prolonged mechanical allodynia in rodents, which temporally correlates with …

A large series of different ion channels have been identified and investigated as potential
targets for new medicines for the treatment of a variety of human diseases, including pain …

Complex regional pain syndrome type I (CRPS-I) is characterized by intractable chronic
pain. Poor understanding of the underlying mechanisms of CRPS-I accounts for the current …

Background and Purpose Although still used by hundreds of millions of people worldwide,
the mechanism of the analgesic action of the pyrazolone derivatives (PD s), dipyrone …

Background The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable
cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and …