Forest soil microbiomes have crucial roles in carbon storage, biogeochemical cycling and
rhizosphere processes. Wildfire season length, and the frequency and size of severe fires …

Background Single-cell RNA sequencing has been widely adopted to estimate the cellular
composition of heterogeneous tissues and obtain transcriptional profiles of individual cells …

Only a subgroup of triple-negative breast cancer (TNBC) responds to immune checkpoint
inhibitors (ICI). To better understand lack of response to ICI, we analyze 681 TNBCs for …

Mutations in the gene coding for the estrogen receptor (ER), ESR1, have been associated
with acquired endocrine resistance in patients with ER-positive metastatic breast cancer …

Differential speeds in biochemical reactions have been proposed to be responsible for the
differences in developmental tempo between mice and humans. However, the underlying …

Objective We assessed whether famotidine improved inflammation and symptomatic
recovery in outpatients with mild to moderate COVID-19. Design Randomised, double-blind …

Cancers are often defined by the dysregulation of specific transcriptional programs;
however, the importance of global transcriptional changes is less understood …

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of
metastasized CRC. Here we present whole genome sequencing data of metastases of 429 …

Cancer germline antigens (CGAs) are expressed in immune-privileged germline tissues,
while epigenetically silenced in somatic tissues. CGAs become re-expressed in tumors and …

Aging is a ubiquitous biological process that limits the maximal lifespan of most organisms.
Significant efforts by many groups have identified mechanisms that, when triggered by …