Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …

The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Recent discoveries have implicated the gut microbiome in the progression and severity of
Parkinson's disease; however, how gut bacteria affect such neurodegenerative disorders …

Lysosomal function has a central role in maintaining neuronal homeostasis, and,
accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to …

Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …

Recently, the genetic variability in lysosomal storage disorders has been implicated in the
pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a …

In recent years, multiple lines of evidence from human genetic and molecular studies have
highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's …