Anxiety disorders are more prevalent in women than in men. In women the menstrual cycle
introduces another variable; indeed, some conditions eg, premenstrual syndrome, are …

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …

The inbred mouse strain, BTBR T+ Itpr3 tf/J (BTBR), possesses neuronal and circuit
abnormalities that underlie atypical behavioral profiles resembling the major symptoms of …

Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

Major depressive disorder (MDD) is the most prevalent mental illness contributing to global
disease burden. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the first-line …

Objective: The prevalence of depression and anxiety is increasing worldwide. Diet as a
modifiable factor for mental health has received great attention. The aim of the present study …

Male and females appear equally capable of showing habituated hypothalamic-pituitary-
adrenal (HPA) axis output responses to repeated exposures of the same challenge. Whether …

Freud-1/Cc2d1a represses the gene transcription of serotonin-1A (5-HT1A) autoreceptors,
which negatively regulate 5-HT tone. To test the role of Freud-1 in vivo, we generated mice …

Elevated plus maze (EPM) tests have been used to assess animal anxiety levels. Little
information is known regarding how physiological activity patterns of the brain-body system …

Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized
by social deficits and restrictive and/or repetitive behaviors. The breadth of ASD symptoms is …