The relationship between autophagy and the immune system and its applications for tumor immunotherapy

GM Jiang, Y Tan, H Wang, L Peng, HT Chen, XJ Meng… - Molecular cancer, 2019 - Springer
Autophagy is a genetically well-controlled cellular process that is tightly controlled by a set of
core genes, including the family of autophagy-related genes (ATG). Autophagy is a “double …

The multifaceted role of autophagy in cancer and the microenvironment

H Folkerts, S Hilgendorf, E Vellenga… - Medicinal research …, 2019 - Wiley Online Library
Autophagy is a crucial recycling process that is increasingly being recognized as an
important factor in cancer initiation, cancer (stem) cell maintenance as well as the …

A micro/nano-biomimetic coating on titanium orchestrates osteo/angio-genesis and osteoimmunomodulation for advanced osseointegration

L Bai, P Chen, Y Zhao, R Hang, X Yao, B Tang, C Liu… - Biomaterials, 2021 - Elsevier
Osseointegration is a sophisticated bone and implant healing process comprising of initial
hematoma formation, immediate osteoimmunomodulation, angiogenesis, and osteogenesis …

The dual role of Reactive Oxygen Species in autoimmune and inflammatory diseases: evidence from preclinical models

MH Hoffmann, HR Griffiths - Free radical biology and medicine, 2018 - Elsevier
Reactive oxygen species (ROS) are created in cells during oxidative phosphorylation by the
respiratory chain in the mitochondria or by the family of NADPH oxidase (NOX) complexes …

[HTML][HTML] The induction of endothelial autophagy and its role in the development of atherosclerosis

Y Hua, J Zhang, Q Liu, J Su, Y Zhao… - Frontiers in …, 2022 - frontiersin.org
Increasing attention is now being paid to the important role played by autophagic flux in
maintaining normal blood vessel walls. Endothelial cell dysfunction initiates the …

Emerging role of autophagy in anti-tumor immunity: Implications for the modulation of immunotherapy resistance

T Jiang, X Chen, X Ren, JM Yang, Y Cheng - Drug resistance updates, 2021 - Elsevier
Immunotherapies such as CAR-T cell transfer and antibody-targeted therapy have produced
promising clinical outcomes in patients with advanced and metastatic cancer that are …

Intestinal autophagy links psychosocial stress with gut microbiota to promote inflammatory bowel disease

SL Wang, BZ Shao, SB Zhao, X Chang, P Wang… - Cell death & …, 2019 - nature.com
Psychosocial stress is a critical inducing factor of inflammatory bowel diseases (IBD), while
autophagy is a novel central issue of IBD development. The present study investigated the …

Cinnamaldehyde ameliorates LPS-induced cardiac dysfunction via TLR4-NOX4 pathway: the regulation of autophagy and ROS production

H Zhao, M Zhang, F Zhou, W Cao, L Bi, Y Xie… - Journal of Molecular and …, 2016 - Elsevier
Cinnamaldehyde (CA), a major bioactive compound extracted from the essential oil of
Cortex Cinnamomi, exhibits anti-inflammatory activity on endotoxemia. Accumulating …

Dual signaling evoked by oxidized LDLs in vascular cells

A Nègre-Salvayre, N Augé, C Camaré… - Free Radical Biology …, 2017 - Elsevier
The oxidative theory of atherosclerosis relies on the modification of low density lipoproteins
(LDLs) in the vascular wall by reactive oxygen species. Modified LDLs, such as oxidized …

Reactive oxygen species and immune regulation

Z Yang, Z Min, B Yu - International Reviews of Immunology, 2020 - Taylor & Francis
Reactive oxygen species (ROS) is a kind of single electron reduction product of oxygen in
vivo. Because they contain unpaired electrons, ROS has high chemical reactivity. Various …