The spondyloarthropathies comprise ankylosing spondylitis (AS), reactive arthritis, psoriatic
arthritis (PsA) and arthritis associated with inflammatory bowel disease. In this Perspectives …

Ankylosing spondylitis is the prototype of immune-mediated inflammatory rheumatic
diseases grouped under the term spondyloarthritis (SpA). An early diagnosis has now …

The HLA region encodes several molecules that play key roles in the immune system.
Strong association between the HLA region and autoimmune disease (AID) has been …

Antibodies to citrullinated proteins (ACPA), ie, to peptides posttranslationally modified by the
conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis …

Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

There is a growing understanding of the mechanisms by which the influence of the
microbiota projects beyond sites of primary mucosal occupation to other human body …

The human MHC represents the strongest susceptibility locus for autoimmune diseases.
However, the identification of the true predisposing gene (s) has been handicapped by the …

Objective To carry out the first large‐scale population study of the prevalence of HLA–B27 in
the US, which is needed for public health planning purposes because of recent …

Objective The association of HLA–B27 with spondyloarthropathy is one of the strongest
documented for any autoimmune disease. A common hypothesis for this association is the …

HLA-B27 has a high degree of genetic polymorphism, with 105 known subtypes, named
HLA-B* 27: 01 to HLA-B* 27: 106, encoded by 132 alleles. The most common subtypes …