Translation elongation is a key step of protein synthesis, during which the nascent
polypeptide chain extends by one amino acid residue during one elongation cycle. More …

Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …

Extracellular vesicles (EVs) are secreted by myriad cells in culture and also by unicellular
organisms, and their identification in mammalian fluids suggests that EV release also occurs …

In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA
transcript, leading to the functional coupling of transcription and translation. The interactions …

Gram-negative bacteria are intrinsically resistant to drugs because of their double-
membrane envelope structure that acts as a permeability barrier and as an anchor for efflux …

Bacterial ribosome biogenesis and translation occur in the same cellular compartment.
Therefore, a biochemical gate-keeping step is required to prevent error-prone immature …

Nucleotides are at the heart of the most essential biological processes in the cell, be it as
key protagonists in the dogma of molecular biology or by regulating multiple metabolic …

Ribosome assembly is one of the most fundamental processes of gene expression and has
served as a playground for investigating the molecular mechanisms of how protein–RNA …

Abstract Ribosomes of Bacteroidia (formerly Bacteroidetes) fail to recognize Shine-Dalgarno
(SD) sequences even though they harbor the anti-SD (ASD) of 16S rRNA. Inhibition of SD …

Ribosome biogenesis is a key process in all organisms. It relies on coordinated work of
multiple proteins and RNAs, including an array of assembly factors. Among them, the …