[HTML][HTML] 3D bioprinting in cardiac tissue engineering
Heart disease is the main cause of death worldwide. Because death of the myocardium is
irreversible, it remains a significant clinical challenge to rescue myocardial deficiency …
irreversible, it remains a significant clinical challenge to rescue myocardial deficiency …
3D cell-based assays for drug screens: challenges in imaging, image analysis, and high-content analysis
TH Booij, LS Price, EHJ Danen - … Discovery: Advancing Life …, 2019 - journals.sagepub.com
The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …
with high-content imaging and automated analysis, is expected to increase the quality of …
3D printing approaches for cardiac tissue engineering and role of immune modulation in tissue regeneration
Conventional tissue engineering, cell therapy, and current medical approaches were shown
to be successful in reducing mortality rate and complications caused by cardiovascular …
to be successful in reducing mortality rate and complications caused by cardiovascular …
Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ‐on‐a‐Chip Vasculature
Tumor progression relies on the interaction between neoplastic epithelial cells and their
surrounding stromal partners. This cell cross‐talk affects stromal development, and …
surrounding stromal partners. This cell cross‐talk affects stromal development, and …
Discovering and validating cancer genetic dependencies: approaches and pitfalls
A Lin, JM Sheltzer - Nature Reviews Genetics, 2020 - nature.com
Cancer 'genetic dependencies'—genes whose products are essential for cancer cell fitness—
are promising targets for therapeutic development. However, recent evidence has cast doubt …
are promising targets for therapeutic development. However, recent evidence has cast doubt …
3D modeling in cancer studies
OE Atat, Z Farzaneh, M Pourhamzeh, F Taki… - Human Cell, 2022 - Springer
The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …
resistance to chemotherapy. Much of our understanding of the tumor and its …
Mimicking tumor hypoxia in non-small cell lung cancer employing three-dimensional in vitro models
I Ziółkowska-Suchanek - Cells, 2021 - mdpi.com
Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects
cancer progression, metastasis and metabolism. Oxygen induces both proteomic and …
cancer progression, metastasis and metabolism. Oxygen induces both proteomic and …
[HTML][HTML] Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development
J Bourland, J Fradette, FA Auger - Scientific reports, 2018 - nature.com
While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery
and improve clinical translation, new human cell-based in vitro models are needed. Our …
and improve clinical translation, new human cell-based in vitro models are needed. Our …
Nanostars on nanopipette tips: A Raman probe for quantifying oxygen levels in hypoxic single cells and tumours
Multiple sharp‐edged gold nanostars were efficiently assembled on nanopipette tips
through electrostatic interactions for use as a potent intracellular hypoxia‐sensing Raman …
through electrostatic interactions for use as a potent intracellular hypoxia‐sensing Raman …
3D cancer models: Depicting cellular crosstalk within the tumour microenvironment
T Franchi-Mendes, R Eduardo, G Domenici, C Brito - Cancers, 2021 - mdpi.com
Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …
cells that communicate with the tumour cells, influencing their behaviour and impacting the …