Noise-induced cochlear synaptopathy: Past findings and future studies
For decades, we have presumed the death of hair cells and spiral ganglion neurons are the
main cause of hearing loss and difficulties understanding speech in noise, but new findings …
main cause of hearing loss and difficulties understanding speech in noise, but new findings …
Efferent inhibition of the cochlea
PA Fuchs, AM Lauer - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Cholinergic efferent neurons originating in the brainstem innervate the acoustico-lateralis
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit …
organs (inner ear, lateral line) of vertebrates. These release acetylcholine (ACh) to inhibit …
Communication breakdown: the impact of ageing on synapse structure
RS Petralia, MP Mattson, PJ Yao - Ageing research reviews, 2014 - Elsevier
Impaired synaptic plasticity is implicated in the functional decline of the nervous system
associated with ageing. Understanding the structure of ageing synapses is essential to …
associated with ageing. Understanding the structure of ageing synapses is essential to …
A Gata3–Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing
Information flow through neural circuits is determined by the nature of the synapses linking
the subtypes of neurons. How neurons acquire features distinct to each synapse remains …
the subtypes of neurons. How neurons acquire features distinct to each synapse remains …
Recent advances in the study of age-related hearing loss: a mini-review
AR Kidd III, J Bao - Gerontology, 2012 - karger.com
Hearing loss is a common age-associated affliction that can result from the loss of hair cells
and spiral ganglion neurons (SGNs) in the cochlea. Although hair cells and SGNs are …
and spiral ganglion neurons (SGNs) in the cochlea. Although hair cells and SGNs are …
Phytosterols reverse antiretroviral-induced hearing loss, with potential implications for cochlear aging
AO Sodero, VC Castagna, SD Elorza… - PLoS …, 2023 - journals.plos.org
Cholesterol contributes to neuronal membrane integrity, supports membrane protein
clustering and function, and facilitates proper signal transduction. Extensive evidence has …
clustering and function, and facilitates proper signal transduction. Extensive evidence has …
Preventing presbycusis in mice with enhanced medial olivocochlear feedback
“Growing old” is the most common cause of hearing loss. Age-related hearing loss
(ARHL)(presbycusis) first affects the ability to understand speech in background noise, even …
(ARHL)(presbycusis) first affects the ability to understand speech in background noise, even …
Efferent synapses return to inner hair cells in the aging cochlea
Efferent innervation of the cochlea undergoes extensive modification early in development,
but it is unclear if efferent synapses are modified by age, hearing loss, or both. Structural …
but it is unclear if efferent synapses are modified by age, hearing loss, or both. Structural …
The α9α10 nicotinic acetylcholine receptor: a compelling drug target for hearing loss?
AB Elgoyhen - Expert opinion on therapeutic targets, 2022 - Taylor & Francis
Introduction Hearing loss is a major health problem, impacting education, communication,
interpersonal relationships, and mental health. Drugs that prevent or restore hearing are …
interpersonal relationships, and mental health. Drugs that prevent or restore hearing are …
Talking back: development of the olivocochlear efferent system
MM Frank, LV Goodrich - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Developing sensory systems must coordinate the growth of neural circuitry spanning from
receptors in the peripheral nervous system (PNS) to multilayered networks within the central …
receptors in the peripheral nervous system (PNS) to multilayered networks within the central …