Evolutionary turnover of kinetochore proteins: a ship of Theseus?
IA Drinnenberg, S Henikoff, HS Malik - Trends in cell biology, 2016 - cell.com
The kinetochore is a multiprotein complex that mediates the attachment of a eukaryotic
chromosome to the mitotic spindle. The protein composition of kinetochores is similar across …
chromosome to the mitotic spindle. The protein composition of kinetochores is similar across …
[HTML][HTML] DNA sequence-specific binding of CENP-B enhances the fidelity of human centromere function
Human centromeres are specified by a stably inherited epigenetic mark that maintains
centromere position and function through a two-step mechanism relying on self-templating …
centromere position and function through a two-step mechanism relying on self-templating …
The genetics and epigenetics of satellite centromeres
PB Talbert, S Henikoff - Genome Research, 2022 - genome.cshlp.org
Centromeres, the chromosomal loci where spindle fibers attach during cell division to
segregate chromosomes, are typically found within satellite arrays in plants and animals …
segregate chromosomes, are typically found within satellite arrays in plants and animals …
DNA sequences in centromere formation and function
M Dumont, D Fachinetti - Centromeres and Kinetochores: Discovering the …, 2017 - Springer
Faithful chromosome segregation during cell division depends on the centromere, a
complex DNA/protein structure that links chromosomes to spindle microtubules. This …
complex DNA/protein structure that links chromosomes to spindle microtubules. This …
[HTML][HTML] Phylogenetic analysis of the Tc1/mariner superfamily reveals the unexplored diversity of pogo-like elements
Background Tc1/mariner transposons are widespread DNA transposable elements (TEs)
that have made important contributions to the evolution of host genomic complexity in …
that have made important contributions to the evolution of host genomic complexity in …
Pogo-like Transposases Have Been Repeatedly Domesticated into CENP-B-Related Proteins
L Mateo, J Gonzalez - Genome biology and evolution, 2014 - academic.oup.com
The centromere is a chromatin region that is required for accurate inheritance of eukaryotic
chromosomes during cell divisions. Among the different centromere-associated proteins …
chromosomes during cell divisions. Among the different centromere-associated proteins …
[HTML][HTML] Chromatin Dynamics in Vivo: A Game of Musical Chairs
Histones are a major component of chromatin, the nucleoprotein complex fundamental to
regulating transcription, facilitating cell division, and maintaining genome integrity in almost …
regulating transcription, facilitating cell division, and maintaining genome integrity in almost …
[HTML][HTML] Clinical and molecular features of anti-CENP-B autoantibodies
RM Prasad, A Bellacosa, TJ Yen - Journal of Molecular Pathology, 2021 - mdpi.com
Centromeric proteins are the foundation for assembling the kinetochore, a macromolecular
complex that is essential for accurate chromosome segregation during mitosis. Anti …
complex that is essential for accurate chromosome segregation during mitosis. Anti …
[HTML][HTML] Genomic instability genes in lung and colon adenocarcinoma indicate organ specificity of transcriptomic impact on Copy Number Alterations
Genomic instability (GI) in cancer facilitates cancer evolution and is an exploitable target for
therapy purposes. However, specific genes involved in cancer GI remain elusive. Causal …
therapy purposes. However, specific genes involved in cancer GI remain elusive. Causal …
JRK binds satellite III DNA and is necessary for the heat shock response
R Waldron, MAB Rodriguez, JM Williams… - Cell Biology …, 2024 - Wiley Online Library
JRK is a DNA‐binding protein of the pogo superfamily of transposons, which includes the
well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and …
well‐known centromere binding protein B (CENP‐B). Jrk null mice exhibit epilepsy, and …