N, O-containing five-membered heterocycles especially oxazole and isoxazole, have widely
been found in many natural products and drugs with relevant medicinal and pharmaceutical …

Ligand/protein binding (LPB) is a major topic in medicine, chemistry and biology. Since the
advent of computers, many scientists have put efforts in developing theoretical models that …

A high-fat diet (HFD) causes hyperlipidemia, which worsens disturbances in bile acid (BA)
metabolism and gut microbiota. This study aimed to investigate the regulation of flavonoids …

The detailed understanding of the binding of small molecules to proteins is the key for the
development of novel drugs or to increase the acceptance of substrates by enzymes …

Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and
glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been …

Farnesoid X receptor (FXR) influences bile acid homeostasis and the progression of various
diseases. While the roles of hepatic and intestinal FXR in enterohepatic transport of bile …

A series of new isoxazolederivatives incorporating the sulfonate ester function has been
synthesized from 2-benzylidenebenzofuran-3 (2 H)-one, known as aurone. The synthesis of …

Background Skeletal muscle generates force and movements and maintains posture. Under
pathological conditions, muscle fibers suffer an imbalance in protein synthesis/degradation …

The farnesoid-X-receptor (FXR) is validated target in the cholestatic disorders treatment.
Obeticholic acid (OCA), the first in class of FXR agonist approved for clinical use, causes …

A new series of N‐substituted pyrazoline derivatives 6a–g, 7a–g, 8a–g, and 9a–g was
synthetized by reaction of hydrazine derivatives and chalcone–thiazole hybrids bearing …