EMT and EndMT: emerging roles in age-related macular degeneration

DY Shu, E Butcher, M Saint-Geniez - International journal of molecular …, 2020 - mdpi.com
Epithelial–mesenchymal transition (EMT) and endothelial–mesenchymal transition (EndMT)
are physiological processes required for normal embryogenesis. However, these processes …

[HTML][HTML] Non-coding RNAs regulating epithelial-mesenchymal transition: Research progress in liver disease

X Yang, Z Jiang, Y Li, Y Zhang, Y Han, L Gao - Biomedicine & …, 2022 - Elsevier
Chronic liver injury could gradually progress to liver fibrosis, cirrhosis, and even hepatic
carcinoma without effective treatment. The massive production and activation of abnormal …

Luteolin Alleviates Epithelial‐Mesenchymal Transformation Induced by Oxidative Injury in ARPE‐19 Cell via Nrf2 and AKT/GSK‐3β Pathway

L Chen, Y Zhu, J Zhou, R Wu, N Yang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Oxidative stress plays a critical role in age‐related macular degeneration (AMD), and
epithelial‐mesenchymal transition (EMT) is involved in this process. The aim of this study …

Polarity and epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

H Zou, C Shan, L Ma, J Liu, N Yang, J Zhao - PeerJ, 2020 - peerj.com
Under physiological conditions, retinal pigment epithelium (RPE) is a cellular monolayer
composed of mitotically quiescent cells. Tight junctions and adherens junctions maintain the …

NEAT1: a novel long non-coding RNA involved in mediating type 2 diabetes and its various complications

D Jia, Y He, Y Wang, M Xue, L Zhu… - Current …, 2022 - ingentaconnect.com
Background: Nuclear128; enriched abundant transcript 1 (abbreviated as NEAT1) is a long-
chain noncoding RNA involved in various physiological and pathological processes. This …

Status of higher TGF-β1 and TGF-β2 levels in the aqueous humour of patients with diabetes and cataracts

C Gao, X Lin, F Fan, X Liu, H Wan, T Yuan, X Zhao… - BMC …, 2022 - Springer
Background Transforming growth factor (TGF) is a cytokine that acts on the proliferation,
migration, differentiation, and apoptosis of cells and the accumulation of extracellular matrix …

Blocking connexin43 hemichannels prevents TGF‐β2 upregulation and epithelial–mesenchymal transition in retinal pigment epithelial cells

H Lyon, N Yin, ID Rupenthal, CR Green… - Cell biology …, 2022 - Wiley Online Library
Epithelial–mesenchymal transition (EMT) occurs when polarised epithelial cells change to a
mesenchymal phenotype. EMT plays a role in several chronic conditions, including ocular …

Exosomal miR-4488 and miR-1273g-5p inhibit the epithelial-mesenchymal transition of transforming growth factor β2-mediated retinal pigment epithelial cells by …

H Dong, M Wang, Q Li - Bioengineered, 2021 - Taylor & Francis
Exosomal microRNAs (miRNAs) have been shown to be involved in the regulation of many
disease progression, including proliferative vitreoretinopathy (PVR). However, the roles of …

The intervention of epithelial-mesenchymal transition in homeostasis of human retinal pigment epithelial cells: a review

B Gelat, P Rathaur, P Malaviya, B Patel… - Journal of …, 2022 - Taylor & Francis
The health and activity of photoreceptors and Bruch's membrane are promoted by the retinal
pigment epithelium (RPE), which is essential for normal vision. Age-related macular …

Idelalisib inhibits experimental proliferative vitroretinopathy

L Dong, H Han, X Huang, G Ma, D Fang, H Qi… - Laboratory …, 2022 - nature.com
Proliferative vitreoretinopathy (PVR) is a fibrotic eye disease that develops after
rhegmatogenous retinal detachment surgery and open-globe traumatic injury. Idelalisib is a …