Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …

The purpose of this white paper is to provide a succinct summary of the different
experimental approaches that have been used in preclinical post-operative cognitive …

Study objective To evaluate the efficacy of perioperative dexmedetomidine (DEX)
administration for preventing delirium in adults after non-cardiac surgery. Design Systematic …

Purpose For over 150 years of anesthetic practice, it was believed that the effects of general
anesthetics were temporary and not adverse. A growing number of studies over the past 2 …

Orexin (also known as hypocretin) neurons in the hypothalamus play an essential role in
sleep–wake control, feeding, reward, and energy homeostasis. The likelihood of anesthesia …

Importance Postpartum depression (PPD) is emerging as a major public health problem
worldwide. Although the particular period and context in which PPD occurs provides an …

General anesthetic drugs cause cognitive deficits that persist after the drugs have been
eliminated. Astrocytes may contribute to such cognition-impairing effects through the release …

Background Delirium after cardiac surgery is associated with adverse outcomes, including
prolonged hospital stay, prolonged intensive care unit stay, and increased mortality …

Neuroscientists have recognized the importance of astrocytes in regulating neurological
function and their influence on the release of glial transmitters. Few studies, however, have …

The activation of NLRP3 inflammasome in microglia is critical for neuroinflammation during
postoperative cognitive dysfunction (POCD) induced by sevoflurane. However, the …