The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

Cerebral white matter exhibits age-related degenerative changes during the course of
normal aging, including decreases in axon density and alterations in axonal structure …

Physiological aging affects brain structure and function impacting morphology, connectivity,
and performance. However, whether some brain connectivity metrics might reflect the age of …

The myeloarchitecture of the corpus callosum (CC) is characterized as a mosaic of distinct
differences in fiber density of small-and large-diameter axons along the anterior–posterior …

Diffusion MRI is extensively used to investigate changes in white matter microstructure.
However, diffusion measures within white matter tissue can be affected by partial volume …

White matter hyperintensity (WMH) lesions on T2 fluid‐attenuated inversion recovery
(FLAIR) magnetic resonance imaging (MRI) and changes in adjacent normal‐appearing …

Normal aging is accompanied by structural degeneration and glucose hypometabolism in
the human brain. However, the relationship between structural network disconnections and …

The ageing process is complex and heterogeneous. Incorporating biological and
psychological measures may improve accuracy in reflecting an individual's 'true age,'and …