Hyperuricemia and its related diseases: mechanisms and advances in therapy

L Du, Y Zong, H Li, Q Wang, L Xie, B Yang… - … and Targeted Therapy, 2024 - nature.com
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

[HTML][HTML] Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome

A Lonardo, S Ballestri, G Marchesini, P Angulo… - Digestive and Liver …, 2015 - Elsevier
The conventional paradigm of nonalcoholic fatty liver disease representing the “hepatic
manifestation of the metabolic syndrome” is outdated. We identified and summarized …

[HTML][HTML] The role of xanthine oxidoreductase and uric acid in metabolic syndrome

MG Battelli, M Bortolotti, L Polito, A Bolognesi - Biochimica et Biophysica …, 2018 - Elsevier
Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome
through the oxidative stress and the inflammatory response induced by XOR-derived …

Allopurinol hypersensitivity: a systematic review of all published cases, 1950–2012

SN Ramasamy, CS Korb-Wells, DRW Kannangara… - Drug safety, 2013 - Springer
Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

[HTML][HTML] Metabolic syndrome and cancer risk: the role of xanthine oxidoreductase

MG Battelli, M Bortolotti, L Polito, A Bolognesi - Redox biology, 2019 - Elsevier
Obesity and related pathologies such as diabetes and metabolic syndrome are associated
with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is …

Dose-response relationship of serum uric acid with metabolic syndrome and non-alcoholic fatty liver disease incidence: a meta-analysis of prospective studies

Z Liu, S Que, L Zhou, S Zheng - Scientific Reports, 2015 - nature.com
Emerging evidence has shown that serum uric acid (SUA) elevation might cause metabolic
derangements, including metabolic syndrome (MetS) and non-alcoholic fatty liver disease …

Serum uric acid: a strong and independent predictor of metabolic syndrome after adjusting for body composition

TY Yu, JH Jee, JC Bae, SM Jin, JH Baek, MK Lee… - Metabolism, 2016 - Elsevier
Background Some observational studies have suggested that serum uric acid (SUA) levels
are one of the determinants of the metabolic syndrome (MetS). However, previous studies …

A confirmatory factor analysis of the metabolic syndrome in adolescents: an examination of sex and racial/ethnic differences

MJ Gurka, CL Ice, SS Sun, MD DeBoer - Cardiovascular Diabetology, 2012 - Springer
Abstract Objective The metabolic syndrome (MetS) is a cluster of clinical indices that signals
increased risk for cardiovascular disease and Type 2 diabetes. The diagnosis of MetS is …

Elevated serum uric acid and risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease: a meta-analysis

R Wang, Y Song, Y Yan, Z Ding - Atherosclerosis, 2016 - Elsevier
Background and aims Serum uric acid (SUA) has been recognized as an independent risk
factor for mortality in the general population. We performed this meta-analysis to determine …

Association between metabolic syndrome and uric acid: a systematic review and meta-analysis

E Raya-Cano, M Vaquero-Abellán, R Molina-Luque… - Scientific Reports, 2022 - nature.com
This systematic review and meta-analysis aim to provide the best evidence on the
association between metabolic syndrome (MetS) and uric acid (UA) by determining the size …