The endoplasmic reticulum (ER) is an essential organelle involved in many cellular
functions including protein folding and secretion, lipid biosynthesis, and calcium …

The endoplasmic reticulum (ER) is the biggest organelle in most cell types, but its
characterization as an organelle with a continuous membrane belies the fact that the ER is …

Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum–associated
degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated …

The endoplasmic reticulum (ER) is an essential compartment of the biosynthesis, folding,
assembly, and trafficking of secretory and transmembrane proteins, and consequently …

Activated mast cells (MCs) release histamine (HA) and MCs infiltrate the liver following bile
duct ligation (BDL), increasing intrahepatic bile duct mass (IBDM) and fibrosis. We evaluated …

The recent identification of metastasis suppressor genes, the products of which inhibit
metastasis but not primary tumor growth, distinguishes oncogenic transformation and tumor …

Abstract Heat-shock protein 5 (HSPA5) is a marker for poor prognosis in breast cancer
patients and has an important role in cancer progression, including promoting drug …

As per the requirement of metabolism and fitness, normal cellular functions are controlled by
several proteins, and their interactive molecular and signaling events at multiple levels …

Nonalcoholic steatohepatitis (NASH) is related to metabolic dysregulation and the
perturbation of endoplasmic reticulum (ER) homeostasis that frequently develops into …

The endoplasmic reticulum‐associated degradation (ERAD) machinery selects native and
misfolded polypeptides for dislocation across the ER membrane and proteasomal …