Tobacco smoke induces and alters immune responses in the lung triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review

A Strzelak, A Ratajczak, A Adamiec… - International journal of …, 2018 - mdpi.com
Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

PJ Barnes, SD Shapiro… - European Respiratory …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading cause of death and disability, but has
only recently been extensively explored from a cellular and molecular perspective. There is …

[HTML][HTML] Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip

KH Benam, R Novak, J Nawroth, M Hirano-Kobayashi… - Cell systems, 2016 - cell.com
Smoking represents a major risk factor for chronic obstructive pulmonary disease (COPD),
but it is difficult to characterize smoke-induced injury responses under physiological …

Tight junctions in pulmonary epithelia during lung inflammation

OH Wittekindt - Pflügers Archiv-European Journal of Physiology, 2017 - Springer
Inflammatory lung diseases like asthma bronchiale, chronic obstructive pulmonary disease
and allergic airway inflammation are widespread public diseases that constitute an …

Oxidative stress and redox regulation of lung inflammation in COPD

I Rahman, IM Adcock - European respiratory journal, 2006 - Eur Respiratory Soc
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

KF Chung, IM Adcock - European Respiratory Journal, 2008 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality
that is characterised by inexorable deterioration of small airways obstruction with …

Acute effects of cigarette smoke on inflammation and oxidative stress: a review

H van der Vaart, DS Postma, W Timens… - Thorax, 2004 - thorax.bmj.com
Compared with the effects of chronic smoke exposure on lung function and airway
inflammation, there are few data on the acute effects of smoking. A review of the literature …

Mediators of chronic obstructive pulmonary disease

PJ Barnes - Pharmacological reviews, 2004 - ASPET
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke

J Milara, T Peiró, A Serrano, J Cortijo - Thorax, 2013 - thorax.bmj.com
Background Cigarette smoking contributes to lung remodelling in chronic obstructive
pulmonary disease (COPD). As part of remodelling, peribronchiolar fibrosis is observed in …

Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease

T Yoshida, RM Tuder - Physiological reviews, 2007 - journals.physiology.org
Chronic obstructive pulmonary diseases (COPD), comprised of pulmonary emphysema,
chronic bronchitis, and structural and inflammatory changes of small airways, is a leading …