Exploring the reciprocity between pioneer factors and development
MM Freund, MM Harrison, EF Torres-Zelada - Development, 2024 - journals.biologists.com
Development is regulated by coordinated changes in gene expression. Control of these
changes in expression is largely governed by the binding of transcription factors to specific …
changes in expression is largely governed by the binding of transcription factors to specific …
Sequence-and chemical specificity define the functional landscape of intrinsically disordered regions
I Langstein-Skora, A Schmid, F Huth, D Shabani… - BioRxiv, 2022 - biorxiv.org
Intrinsically disordered protein regions (IDRs) pervasively engage in essential molecular
functions, yet they are often poorly conserved as assessed by sequence alignment. To …
functions, yet they are often poorly conserved as assessed by sequence alignment. To …
Crosstalk between paralogs and isoforms influences p63-dependent regulatory element activity
G Baniulyte, AA McCann, DL Woodstock… - Nucleic Acids …, 2024 - academic.oup.com
The p53 family of transcription factors (p53, p63 and p73) regulate diverse organismal
processes including tumor suppression, maintenance of genome integrity and the …
processes including tumor suppression, maintenance of genome integrity and the …
[HTML][HTML] Context dependent activity of p63-bound gene regulatory elements
AA McCann, G Baniulyte, DL Woodstock… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The p53 family of transcription factors regulate numerous organismal processes including
the development of skin and limbs, ciliogenesis, and preservation of genetic integrity and …
the development of skin and limbs, ciliogenesis, and preservation of genetic integrity and …
Sequence-and chemical specificity define the functional landscape of intrinsically disordered regions
A Holehouse, I Langstein-Skora, A Schmid, F Huth… - 2024 - researchsquare.com
Intrinsically disordered protein regions (IDRs) pervasively engage in essential molecular
functions, yet they are often poorly conserved as assessed by sequence alignment. To …
functions, yet they are often poorly conserved as assessed by sequence alignment. To …
Cross-tissue isoform switches by human transcription factors suggest a widespread regulatory mechanism
Many human genes, including transcription factor (TF) genes, produce alternative coding
isoforms. Although some alternative coding TF isoforms have been experimentally studied, a …
isoforms. Although some alternative coding TF isoforms have been experimentally studied, a …
Alternative splicing across the C. elegans nervous system
A Weinreb, E Varol, A Barrett, RM McWhirter, SR Taylor… - bioRxiv, 2024 - biorxiv.org
Alternative splicing is a key mechanism that shapes neuronal transcriptomes, helping to
define neuronal identity and modulate function. Here, we present an atlas of alternative …
define neuronal identity and modulate function. Here, we present an atlas of alternative …