Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

Laminopathies, caused by mutations in the LMNA gene encoding the nuclear envelope
proteins lamins A and C, represent a diverse group of diseases that include Emery–Dreifuss …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …

Emery‐Dreifuss muscular dystrophy (EDMD) is a rare muscular dystrophy, but is particularly
important to diagnose due to frequent life‐threatening cardiac complications. EDMD …

Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of
disorders including muscular dystrophy and dilated cardiomyopathy. Lamins provide …

Novel therapeutics in areas with a high unmet medical need are based on innovative drug
targets. Although 'biologicals' have enlarged the space of druggable molecules, the number …

The transforming growth factor-beta (TGF-β) superfamily consists of a variety of cytokines
expressed in many different cell types including skeletal muscle. Members of this …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

A-and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in
a plethora of stable and transient interactions, near the inner nuclear membrane and …