Recent updates in venetoclax combination therapies in pediatric hematological malignancies
M Leśniak, J Lipniarska, P Majka, M Lejman… - International Journal of …, 2023 - mdpi.com
Venetoclax is a strongly effective B-cell lymphoma-2 inhibitor (BCL-2) with an ability to
selectively restore the apoptotic potential of cancerous cells. It has been proven that in …
selectively restore the apoptotic potential of cancerous cells. It has been proven that in …
NUP98 oncofusions in myeloid malignancies: An update on molecular mechanisms and therapeutic opportunities
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a
heterogeneous molecular landscape. In the pediatric context, the NUP98 gene is a frequent …
heterogeneous molecular landscape. In the pediatric context, the NUP98 gene is a frequent …
Remission rate, toxicity and pharmacokinetics of venetoclax-based induction regimens in untreated pediatric acute myeloid leukemia
X Wen, Y Lu, Y Li, P Qi, Y Wu, J Yu, R Zhang… - NPJ Precision …, 2024 - nature.com
The efficacy and safety of venetoclax in newly diagnosed pediatric acute myeloid leukemia
(AML) are not well-established as they are in adults. Children newly diagnosed with AML …
(AML) are not well-established as they are in adults. Children newly diagnosed with AML …
Clinical outcomes of hypomethylating agents and venetoclax in newly diagnosed unfit and relapsed/refractory paediatric, adolescent and young adult acute myeloid …
FR LeBlanc, EH Breese, KC Burns… - British Journal of …, 2024 - Wiley Online Library
Venetoclax (VEN) combined with hypomethylating agents (HMA) decitabine or azacitidine is
used for adult acute myeloid leukaemia (AML), but its application in paediatric, adolescent …
used for adult acute myeloid leukaemia (AML), but its application in paediatric, adolescent …
[HTML][HTML] Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts
G Conteduca, D Cangelosi, C Baldo, A Arado, B Testa… - Genes, 2024 - mdpi.com
Germline variants in the NSD1 gene are responsible for Sotos syndrome, while somatic
variants promote neoplastic cell transformation. Our previous studies revealed three …
variants promote neoplastic cell transformation. Our previous studies revealed three …
Pediatric acute myeloid leukemia–novel approaches
SE Karol, G Gueguen - Current Opinion in Hematology, 2024 - journals.lww.com
Recent findings have altered the landscape of pediatric AML therapy with exciting
immediate and long-term implications. Ongoing studies may soon define this as standard as …
immediate and long-term implications. Ongoing studies may soon define this as standard as …
Novel ZFPL1:: NUP98 fusion gene identified in an adult acute myeloid leukemia patient
Y Zhu, Y Chen, F Zhang, M Wang… - International …, 2024 - pubmed.ncbi.nlm.nih.gov
Novel ZFPL1::NUP98 fusion gene identified in an adult acute myeloid leukemia patient Novel
ZFPL1::NUP98 fusion gene identified in an adult acute myeloid leukemia patient Int J Lab …
ZFPL1::NUP98 fusion gene identified in an adult acute myeloid leukemia patient Int J Lab …